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Primal Immune Defense

THE ALL-IN-ONE IMMUNE SUPPORT FORMULA

67 reviews
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THE ALL-IN-ONE IMMUNE SUPPORT FORMULA

  • Doctor-formulated for maximum effectiveness†
  • Featuring zinc and essential vitamins C, B6, D3, and K
  • Supports a healthy immune system and general wellness †
  • 7 billion CFUs of L. acidophilus and Bb-06 probiotics
  • All the benefits of reishi and lion's mane mushrooms †
  • Gluten-free, soy-free, and gelatin-free
  • USA-made in a GMP-certified facility
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Primal Immune Defense

67 reviews
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THE ALL-IN-ONE IMMUNE SUPPORT FORMULA

  • Doctor-formulated for maximum effectiveness†
  • Featuring zinc and essential vitamins C, B6, D3, and K
  • Supports a healthy immune system and general wellness †
  • 7 billion CFUs of L. acidophilus and Bb-06 probiotics
  • All the benefits of reishi and lion's mane mushrooms †
  • Gluten-free, soy-free, and gelatin-free
  • USA-made in a GMP-certified facility
  • 1
    FREE SHIPPING ON ORDERS OF $75 OR MORE
  • 2
    ORDERS BY 3PM SHIP SAME DAY (MON-FRI)*
  • 3
    90-DAY MONEY-BACK GUARANTEE
  • 4
    MADE IN THE USA*

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6 CORE BENEFITS OF OUR

PRIMAL IMMUNE DEFENSE

THE MOST COMPLETE GUT
HEALTH FORMULA

Give your gut everything it needs to reach its optimal state of health with this revolutionary and fast-acting formula. Featuring pre, pro and postbiotics all in one capsule — to strengthen your intestinal barrier, destroy harmful bacteria, and create the ideal environment for healthy gut flora to colonize and flourish.

DESTROY HARMFUL
GUT BACTERIA

An overgrowth of harmful bacteria in the gut can damage a healthy digestive tract and lead to many health concerns. Formulated to target and destroy harmful bacteria within your gut, probiotics reinstill balance to your microbiome. If left unchecked, an unbalanced microbiome can cause serious damage to your immune system.*

INHIBITS PATHOGEN COLONIZATION

Probiotics are designed to fight off harmful pathogens and prevent their replication in your gut’s microbiome. If these harmful pathogens take over your gut, they can cause intestinal infections and a number of other inflammatory diseases.*

DOCTOR-
FORMULATED

Primal Harvest’s Immune Defense is a doctor-formulated 3-step solution for total immune system optimization.†

OPTIMIZES YOUR
GUT HEALTH

This immune-boosting formula features two premium probiotic strains to help balance your gut so that beneficial gut flora can thrive.†

PACKED WITH
VITAMINS & MINERALS

Containing optimum doses of zinc and essential immune defense vitamins C, D3, B6, and K this immunity formula is a must-have in any wellness routine.

PREBIOTICS
FOR LONGEVITY

This formula features GOS prebiotics to help keep the healthy bacteria strong within your gut for a more balanced and active life.†

ADAPTOGENIC
BENEFITS

Expertly-formulated with the adaptogenic mushrooms reishi and organic lion's mane to boost overall wellness and support stress responses. †

LA-14 FOR MAXIMUM
IMMUNE SUPPORT

We’ve included the widely researched probiotic strain Lactobacillus acidophilus (LA-14) for maximum wellness and immune response support.†

PROMOTE HEALTHY
GUT BACTERIA

There are thousands of different types of bacteria in your intestines that collectively make up your microbiome. Your microbiome is responsible for controlling the digestion of food, immune system and central nervous system function, as well as impacting healthy sleep, mood, brain health, and other bodily processes.

REDUCE THE EFFECTS
OF ALLERGIES

Those who suffer from allergies have been found to lack diversity in their gut bacteria. By introducing powerful healing bacteria, Primal Gut Restore gets to the root of the problem to naturally decrease the severity of most allergy symptoms.*

POSTBIOTICS FOR
MAXIMUM EFFECTIVNESS

Postbiotics are the byproduct when prebiotics feed on probiotics. Less widely known than prebiotics and probiotics, postbiotics provide the bases for a strong and healthy gut microbiome. Recent research has even found that most of the benefits we attribute to probiotics are actually due to postbiotic activity.

6 CORE BENEFITS OF OUR

PRIMAL IMMUNE DEFENSE

DOCTOR-FORMULATED

Primal Harvest’s Immune Defense is a doctor-formulated 3-step solution for total immune system optimization.†

OPTIMIZES YOUR GUT HEALTH

This immune-boosting formula features two premium probiotic strains to help balance your gut so that beneficial gut flora can thrive.†

PACKED WITH VITAMINS & MINERALS

Containing optimum doses of zinc and essential immune defense vitamins C, D3, B6, and K this immunity formula is a must-have in any wellness routine.

PREBIOTICS FOR LONGEVITY

This formula features GOS prebiotics to help keep the healthy bacteria strong within your gut for a more balanced and active life.†

ADAPTOGENIC BENEFITS

Expertly formulated with adaptogenic mushrooms like reishi and organic lion's mane to boost wellness and support stress responses.†

LA-14 FOR MAXIMUM IMMUNE SUPPORT

We’ve included the widely researched probiotic strain Lactobacillus acidophilus (LA-14) for maximum wellness and immune response support.†

THE ESSENTIAL IMMUNE BOOSTING FORMULA

Featuring doctor-approved ingredients for optimal immune support.†

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NATURE FOR YOUR HEALTH

COMPLETE INGREDIENT TRANSPARENCY

PRE- AND PROBIOTICS

Primal Immune Defense is expertly formulated with pre- and probiotics. It contains two widely studied probiotic strains, Lactobacillus Acidophilus (LA-14) and Bifidobacterium bifidum (Bb-06), and premium GOS prebiotics to help maintain a healthy immune response.†

DOCTOR-FORMULATED VITAMIN & MINERAL BLEND

Vitamins D3, B6, C, K, and the mineral zinc are vital for immune support. This doctor-formulated blend delivers a concentrated dose of immune defense vitamins and minerals to keep you feeling your best.

Primal Immune Defense is expertly crafted with BioPerine® black pepper extract for maximum absorption and bioavailability in doctor-approved doses.†

POTENT ADAPTOGENS

We’ve included reishi and organic lion’s mane for their immune-supporting and adaptogenic benefits. Used for centuries in ancient Chinese and Japanese cultures, these mushrooms may help support immune response and boost energy levels.†

SUGGESTED USE OF IMMUNE DEFENSE

HOW TO USE

Adults, as a dietary supplement, take two capsules daily, preferably with a morning or afternoon meal, or as recommended by your healthcare provider.*

For best results, combine with a healthy routine that includes balanced meals, exercise, water, and plenty of rest!

*capsules enlarged to show texture to every suggested “Servings per container”

Benefits

†These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

SERVINGS PER CONTAINER

Each bottle of Primal Immune Defense contains 30 servings per container. Recommended daily serving is two capsules per day.

*capsules enlarged to show texture to every suggested “Servings per container”

SUPPLEMENT FACTS

1. As your body adapts to your new supplement routine, it’s important to remember that every individual is different and health benefits may vary from person to person. Always consult with your physician before using this or any other product if you have a preexisting condition or take prescription medication.
2. If you are pregnant, nursing, taking medication, or have an existing condition, be sure to consult with your physician before taking this or any other dietary supplement.
3. Store in a cool, dry place. Keep out of reach of children.

* These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*capsules enlarged to show texture to every suggested “Servings per container”

Adults, as a dietary supplement, take two capsules daily, preferably with a morning or afternoon meal, or as recommended by your healthcare provider.*

For best results, combine with a healthy routine that includes balanced meals, exercise, water, and plenty of rest!

*capsules enlarged to show texture to every suggested “Servings per container”

*capsules enlarged to show texture to every suggested “Servings per container”

Each bottle of Primal Immune Defense contains 30 servings per container. Recommended daily serving is two capsules per day.

*capsules enlarged to show texture to every suggested “Servings per container”

1. As your body adapts to your new supplement routine, it’s important to remember that every individual is different and health benefits may vary from person to person. Always consult with your physician before using this or any other product if you have a preexisting condition or take prescription medication.
2. If you are pregnant, nursing, taking medication, or have an existing condition, be sure to consult with your physician before taking this or any other dietary supplement.
3. Store in a cool, dry place. Keep out of reach of children.

* These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*capsules enlarged to show texture to every suggested “Servings per container”

Adults, as a dietary supplement, take two capsules daily, preferably with a morning or afternoon meal, or as recommended by your healthcare provider.*

For best results, combine with a healthy routine that includes balanced meals, exercise, water, and plenty of rest!

*Capsules enlarged to show texture to every suggested “Servings per container”

†These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Each bottle of Primal Immune Defense contains 30 servings per container, a one-month supply. The recommended daily serving is 2 capsules per day.

(Capsules enlarged to show texture to every suggested “Servings per container”)

1. As your body adapts to your new supplement routine, it’s important to remember that every individual is different and health benefits may vary from person to person. Always consult with your physician before using this or any other product if you have a preexisting condition or take prescription medication.
2. If you are pregnant, nursing, taking medication, or have an existing condition, be sure to consult with your physician before taking this or any other dietary supplement.
3. Store in a cool, dry place. Keep out of reach of children.

†These statements have not been approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
*Capsules enlarged to show texture to every suggested “Servings per container”

DON'T TAKE OUR WORD FOR IT

DON'T TAKE OUR WORD FOR IT

HEAR WHAT OUR CUSTOMERS ARE SAYING!

HEAR WHAT OUR CUSTOMERS ARE SAYING!

PRIMAL IMMUNE DEFENSE REVIEWS

check out the most recent Primal Immune Defense reviews created by our customers

FREQUENTLY ASKED QUESTIONS

WHAT IS PRIMAL IMMUNE DEFENSE? 

Primal Immune Defense is a doctor-formulated immune support blend that takes a 360° holistic approach to protecting your wellness.

Primal Immune Defense contains prebiotics, probiotics, mushroom extract, vitamins, and zinc to supercharge your immune system, aid immune response maintenance, and keep you ready to tackle whatever life throws your way.†

WHAT ARE PROBIOTIC STRAINS?

Probiotic strains are the different types of probiotics, also known as the beneficial bacteria found within our gut microbiota. Each strain has a different effect on the body. Some are great for digestion, while others can help to support your immune system.†

WHY CHOOSE PRIMAL IMMUNE DEFENSE?

Primal Immune Defense helps you support a healthy immune system naturally. Probiotics work to optimize your microbiome and line your intestinal walls with beneficial gut bacteria. Primal Immune Defense helps deliver potent probiotic strains like Lactobacillus acidophilus (La-14) for powerfu immune support. It also provides prebiotics to ensure the longevity of these immune boosting probiotic strains.†

Primal Immune Defense is loaded with vitamins C, D3, B6, K, zinc, and mushroom extracts to help strengthen your natural defenses.†

WHAT IS THE BEST WAY TO USE PRIMAL IMMUNE DEFENSE?  

We recommend that you take your 2 capsules daily with your morning breakfast, brunch, or afternoon lunch. Since consistency is key to getting the most out of your Immune Defense, we recommend picking a time and sticking to it each day.

HOW LONG WILL A BOTTLE OF PRIMAL IMMUNE DEFENSE LAST?

Each bottle contains 30 servings (or a one-month supply).

ARE THERE ANY ALLERGY CONCERNS WITH THIS PRODUCT? 

This product is manufactured in a facility that also processes tree nuts, peanuts, wheat, and soy. Always review the label for the most accurate information, and check with your doctor if you have any concerns.

CAN I TAKE THIS PRODUCT IF I HAVE A MEDICAL CONDITION? 

Primal Immune Defense is intended for use by healthy adults over 18 years old. We recommend that you consult with your physician before use if you are taking any prescription or over-the-counter medications or are being treated for any existing medical conditions.

HOW LONG WILL IT TAKE FOR MY BOTTLE OF PRIMAL IMMUNE DEFENSE TO ARRIVE?

Domestic orders received before 3 pm EST will ship the same day, with the exception of major holidays. If your order doesn’t make it out on the same day, not to worry! It will be shipped out the following business day. Please allow 2-4 business days for your package to arrive. In some specific cases, it may take up to 2 extra business days. If ordering from Canada please allow 7-14 business days. We will provide you with a tracking number once the package leaves our warehouse. If you have any questions, please visit our Shipping page here: https://primalharvest.com/policies/shipping-policy.

HOW DO I STORE THIS PRODUCT? 

We have formulated this product to be shelf-stable with a significant overage on total cell enumeration. Probiotic bacteria can be sensitive to certain environments, that’s why we keep them temperature controlled throughout the entire production process, including storage in our warehouse.

Although Primal Immune Defense pills are shelf-stable and specially formulated to maintain maximum efficiency and shelf life, we recommend storing it in a cool, dry place away from moisture, and outside of direct sunlight. Although it’s not required, you can refrigerate your product after opening.

WHAT IS THE SHELF LIFE OF MY PRIMAL IMMUNE DEFENSE PILLS?

Stability studies show that full potency and cell count will be maintained for 18+ months if stored properly and unopened. After 18 months the probiotic is at risk of a decrease in potency and cell count.

Once opened, we recommend finishing an opened bottle within 90 days and storing the opened bottle either in low-moisture conditions.

HOW MANY bottleS SHOULD I PURCHASE?

To take full advantage of our discounts and to help you remain consistent with your routine, we recommend buying multiple bottles of Primal Immune Defense. You are always protected by our 90-day money-back guarantee so you have plenty of time to enjoy the long-term benefits of Primal Immune Defense and make sure it's the right fit for you. For more information on our guarantee, please visit our Returns page: https://primalharvest.com/policies/refund-policy.

If you are using a discount code, please note that your discount code cannot be combined with any other offer or discount code and excludes all sale items and subscription purchases.

WHERE IS PRIMAL IMMUNE DEFENSE MADE?*

Primal Immune Defense is formulated and manufactured in the USA in a GMP-certified facility (Good Manufacturing Practices) according to the highest safety and quality regulations.

It is independently third-party lab tested in the USA and is formulated with premium globally sourced ingredients (both domestic and imported) to ensure we use only the best ingredients available worldwide.*

WHAT DOES IT MEAN IF MY ORDER IS “PENDING”?

There may be a few reasons why your order is listed as “pending:”

1. Incorrect address.

2. Order was placed after processing cut-off time for the day.

3. It is the weekend or special holiday. Orders are only processed Monday-Friday. If you feel that none of those apply to your order feel free to reach out to our Customer Service Department Monday-Friday 9 am - 5 pm EST or email us at support@primalharvest.com

WE GUARANTEE

90-DAY MONEY-BACK GUARANTEE

We want you to be 100% satisfied with all the products you buy at the Primal Harvest Store.

If you're not entirely happy with your purchase, we will refund your money in full, or exchange the products.

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*Primal Harvest products are made and manufactured in the USA using premium, globally-sourced ingredients (both domestic and imported) to ensure we use only the best ingredients available worldwide.

†These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information provided by this website or this company is not a substitute for a face-to-face consultation with your physician and should not be construed as individual medical advice. The testimonials on this website are individual cases and do not guarantee that you will get the same results. All content, including text, graphics, images and information, contained on or available through this web site is for general information purposes only.

Citations

EVALUATION OF SELECTED CULINARY-MEDICINAL MUSHROOMS FOR ANTIOXIDANT AND ACE INHIBITORY ACTIVITIES
Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities. Evid Based Complement Alternat Med. 2012;2012:464238. doi: 10.1155/2012/464238.

CORDYCEPIN FOR HEALTH AND WELLBEING: A POTENT BIOACTIVE METABOLITE OF AN ENTOMOPATHOGENIC CORDYCEPS MEDICINAL FUNGUS AND ITS NUTRACEUTICAL AND THERAPEUTIC POTENTIAL
Ashraf SA, Elkhalifa AEO, Siddiqui AJ, et al. Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Cordyceps Medicinal Fungus and Its Nutraceutical and Therapeutic Potential. Molecules. 2020;25(12):2735. Published 2020 Jun 12. doi:10.3390/molecules25122735.

PROBING LINGZHI OR REISHI MEDICINAL MUSHROOM GANODERMA LUCIDUM (HIGHER BASIDIOMYCETES): A BITTER MUSHROOM WITH AMAZING HEALTH BENEFITS
Batra P, Sharma AK, Khajuria R. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms. 2013;15(2):127-143. doi:10.1615/intjmedmushr.v15.i2.20.

HEALTH EFFECTS AND SOURCES OF PREBIOTIC DIETARY FIBER
Carlson JL, Erickson JM, Lloyd BB, Slavin JL. Health Effects and Sources of Prebiotic Dietary Fiber. Curr Dev Nutr. 2018;2(3):nzy005. Published 2018 Jan 29. doi:10.1093/cdn/nzy005.

EFFECT OF FRUIT PECTIN ON GROWTH OF LACTIC ACID BACTERIA
Chatterjee1 E, Suba GAM, Syed SH. Effect of Fruit Pectin on Growth of Lactic Acid Bacteria. J Prob Health 2016, 4:2; doi: 10.4172/2329-8901.1000147.

THE EFFECTS OF TWO DIFFERENT GANODERMA SPECIES (LINGZHI) ON GENE EXPRESSION IN HUMAN MONOCYTIC THP-1 CELLS
Cheng CH, Leung AY, Chen CF. The effects of two different ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells. Nutr Cancer. 2010;62(5):648-58. doi: 10.1080/01635581003605516.

HYPOLIPIDAEMIC EFFECT OF HERICIUM ERINACEUM GROWN IN ARTEMISIA CAPILLARIS ON OBESE RATS
Choi WS, Kim YS, Park BS, Kim JE, Lee SE. Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats. Mycobiology. 2013;41(2):94-99. doi:10.5941/MYCO.2013.41.2.94.

STUDY OF POTENTIAL CARDIOPROTECTIVE EFFECTS OF GANODERMA LUCIDUM (LINGZHI): RESULTS OF A CONTROLLED HUMAN INTERVENTION TRIAL
Chu TT, Benzie IF, Lam CW, Fok BS, Lee KK, Tomlinson B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br J Nutr. 2012;107(7):1017-1027. doi:10.1017/S0007114511003795.

MICRONUTRIENT INADEQUACIES IN THE US POPULATION: AN OVERVIEW
Drake VJ. Micronutrient inadequacies in the US Population: An Overview. Linus Pauling Institute Oregon State University. Updated 2018. Accessed June 1 2021. https://lpi.oregonstate.edu/mic/micronutrient-inadequacies/overview.

CHEMISTRY, NUTRITION, AND HEALTH-PROMOTING PROPERTIES OF HERICIUM ERINACEUS (LION’S MANE) MUSHROOM FRUITING BODIES AND MYCELIA AND THEIR BIOACTIVE COMPOUNDS
Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. J Agric Food Chem. 2015;63(32):7108-7123. doi:10.1021/acs.jafc.5b02914.


PURIFICATION, CHARACTERIZATION, AND PREBIOTIC PROPERTIES OF PECTIC OLIGOSACCHARIDES FROM ORANGE PEEL WASTES 
Gómez B, Gullón B, Remoroza C, Schols HA, Parajó JC, Alonso JL. Purification, characterization, and prebiotic properties of pectic oligosaccharides from orange peel wastes. J Agric Food Chem. 2014;62(40):9769-9782. doi:10.1021/jf503475b.


APPLE-DERIVED PECTIN MODULATES GUT MICROBIOTA, IMPROVES GUT BARRIER FUNCTION, AND ATTENUATES METABOLIC ENDOTOXEMIA IN RATS WITH DIET-INDUCED OBESITY
Jiang T, Gao X, Wu C, et al. Apple-Derived Pectin Modulates Gut Microbiota, Improves Gut Barrier Function, and Attenuates Metabolic Endotoxemia in Rats with Diet-Induced Obesity. Nutrients. 2016;8(3):126. Published 2016 Feb 29. doi:10.3390/nu8030126.

HERICIUM ERINCEUS MUSHROOM EXTRACT PROTECT INFECTED MICE AGAINST SALMONELLA TYPHIMURIUM-INDUCED LIVER DAMAGE AND MORTALITY BY STIMULATION OF INNATE IMMUNE CELLS
Kim SP, Moon E, Nam SH, Friedman M. Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-Induced liver damage and mortality by stimulation of innate immune cells. J Agric Food Chem. 2012;6;60(22):5590-6. doi: 10.1021/jf300897w.

NEUROTROPHIC PROPERTIES OF THE LION’S MANE MEDICINAL MUSHROOM, HERICIUM ERINACEUS (HIGHER BASIDIOMYCETES) FROM MALAYSIA
Lai PL, Naidu M, Sabaratnam V, et al. Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-554. doi:10.1615/intjmedmushr.v15.i6.30.

HAEMATOLOGICAL, BIOCHEMICAL AND HISTOPATHOLOGICAL ASPECTS OF HERICIUM ERINACEUS INGESTION IN A RODENT MODEL: A SUB-CHRONIC TOXICOLOGICAL ASSESSMENT
Lakshmanan H, Raman J, David P, Wong KH, Naidu M, Sabaratnam V. Haematological, biochemical and histopathological aspects of Hericium erinaceus ingestion in a rodent model: A sub-chronic toxicological assessment. J Ethnopharmacol. 2016 Dec 24;194:1051-1059. doi: 10.1016/j.jep.2016.10.084.

PROTECTIVE EFFECTS OF HERICIUM ERINACEUS MYCELIUM AND ITS ISOLATED ERINACINE A AGAINST ISCHEMIA-INJURY-INDUCED NEURONAL CELL DEATH VIA THE INHIBITION OF INOS/P38 MAPK AND NITROTYROSINE
Lee KF, Chen JH, Teng CC, et al. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014;15(9):15073-15089. Published 2014 Aug 27. doi:10.3390/ijms150915073.

NEUROHEALTH PROPERTIES OF HERICIUM ERINACEUS MYCELIA ENRICHED WITH ERINACINES
Li IC, Lee LY, Tzeng TT, et al. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behav Neurol. 2018;2018:5802634. Published 2018 May 21. doi:10.1155/2018/5802634.  

CELLULAR AND MOLECULAR MECHANISMS OF IMMUNO-MODULATION BY GANODERMA LUCIDUM
Lin ZB. Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum. J Pharmacol Sci. 2005;99(2):144-53. doi: 10.1254/jphs.crj05008x.

MEDICINAL MUSHROOMS
Lindequist U, Kim HW, Tiralongo E, Van Griensven L. Medicinal mushrooms. Evid Based Complement Alternat Med. 2014;2014:806180. doi:10.1155/2014/806180.

EFFECTS OF HERICIUM ERINACEUS ON AMYLOID β(25-35) PEPTIDE-INDUCED LEARNING AND MEMORY DEFICITS IN MICE
Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N. Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Biomed Res. 2011;32(1):67-72. doi:10.2220/biomedres.32.67.

COMPARISON OF THE IN VITRO BIFIDOGENIC PROPERTIES OF PECTINS AND PECTIC-OLIGOSACCHARIDES
Olano-Martin E, Gibson GR, Rastell RA. Comparison of the in vitro bifidogenic properties of pectins and pectic-oligosaccharides. J Appl Microbiol. 2002;93(3):505-511. doi:10.1046/j.1365-2672.2002.01719.x.

HERCIUM ERINACEUS IMPROVES RECOGNITION MEMORY AND INDUCES HIPPOCAMPAL AND CEREBELLAR NEUROGENESIS IN FRAIL MICE DURING AGING
Ratto D, Corana F, Mannucci B, et al. Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging. Nutrients. 2019;11(4):715. Published 2019 Mar 27. doi:10.3390/nu11040715.


HERICIUM ERINACEUS EXTRACT REDUCES ANXIETY AND DEPRESSIVE BEHAVIORS BY PROMOTING HIPPOCAMPAL NEUROGENESIS IN THE ADULT MOUSE BRAIN
Ryu S, Kim HG, Kim JY, Kim SY, Cho KO. Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain. J Med Food. 2018;21(2):174-180. doi:10.1089/jmf.2017.4006.

PHARMACOLOGICAL AND THERAPEUTIC POTENTIAL OF CORDYCEPS WITH SPECIAL REFERENCE TO CORDYCEPIN
Tuli HS, Sandhu SS, Sharma AK. Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech. 2014;4(1):1-12. doi:10.1007/s13205-013-0121-9.

EDIBLE MUSHROOMS: IMPROVING HUMAN HEALTH AND PROMOTING QUALITY LIFE
Valverde ME, Hernández-Pérez T, Paredes-López O. Edible mushrooms: improving human health and promoting quality life. Int J Microbiol. 2015;2015:376387. doi:10.1155/2015/376387.  

PERIPHERAL NERVE REGENERATION FOLLOWING CRUSH INJURY TO RAT PERONEAL NERVE BY AQUEOUS EXTRACT OF MEDICINAL MUSHROOM HERICIUM ERNACIUS
Wong KH, Naidu M, David P, et al. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae) [published correction appears in Evid Based Complement Alternat Med. 2018 Dec 16;2018:9820769]. Evid Based Complement Alternat Med. 2011;2011:580752. doi:10.1093/ecam/neq062.

EFFECTS OF AMYCENOME ON SERUM LEVELS OF TUMOR NECROSIS FACTOR-α, INTERLEUKIN-10, AND DEPRESSION-LIKE BEHAVIOR IN MICE AFTER LIPOPOLYSACCHARIDE ADMINISTRATION
Yao W, Zhang JC, Dong C, et al. Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration. Pharmacol Biochem Behav. 2015;136:7-12. doi:10.1016/j.pbb.2015.06.012.

EFFECT OF GANODERMA LUCIDUM CAPSULES ON T LYPHOCYTE SUBSETS IN FOOTBALL PLAYERS ON “LIVING HIGH-TRAINING LOW”
Zhang Y, Lin Z, Hu Y, Wang F. Effect of Ganoderma lucidum capsules on T lymphocyte subsets in football players on "living high-training low. Br J Sports Med. 2008;42(10):819-22. doi: 10.1136/bjsm.2007.038620.

SPORE POWDER OF GANODERMA LUCIDUM IMPROVES CANCER-RELATED FATIGUE IN BREAST CANCER PATIENTS UNDERGOING ENDOCRINE THERAPY: A PILOT CLINICAL TRIAL
Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614. doi:10.1155/2012/809614.