Primal Immune Defense

THE ALL-IN-ONE IMMUNE SUPPORT FORMULA*

78 reviews
Primal Immune Defense Primal Immune Defense Primal Immune Defense Primal Immune Defense Primal Immune Defense Primal Immune Defense

THE ALL-IN-ONE IMMUNE SUPPORT FORMULA*

  • Doctor-formulated for maximum effectiveness*
  • Featuring zinc and essential vitamins C, B6, D3, and K
  • Supports a healthy immune system and general wellness*
  • 7 billion CFUs of L. acidophilus and Bb-06 probiotics
  • All the benefits of reishi and lion's mane mushrooms*
  • Gluten-free, soy-free, and gelatin-free
  • USA-made in a GMP-certified facility
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Primal Immune Defense

78 reviews
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THE ALL-IN-ONE IMMUNE SUPPORT FORMULA*

  • Doctor-formulated for maximum effectiveness*
  • Featuring zinc and essential vitamins C, B6, D3, and K
  • Supports a healthy immune system and general wellness*
  • 7 billion CFUs of L. acidophilus and Bb-06 probiotics
  • All the benefits of reishi and lion's mane mushrooms*
  • Gluten-free, soy-free, and gelatin-free
  • USA-made in a GMP-certified facility
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    FREE SHIPPING ON ORDERS OF $75 OR MORE
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    ORDERS BY 3PM SHIP SAME DAY (MON-FRI)†
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    MADE IN THE USA†

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6 Core Benefits Of Our
PRIMAL IMMUNE DEFENSE
PRIMAL IMMUNE DEFENSE
Primal Harvest’s Immune Defense is a doctor-formulated 3-step solution for total immune system optimization.*
This immune-boosting formula features two premium probiotic strains to help balance your gut so that beneficial gut flora can thrive.*
Containing optimum doses of zinc and essential vitamins C, D3, B6, and K this immunity formula is a must-have in any wellness routine.
This formula features GOS prebiotics to help keep the healthy bacteria strong and thriving within your gut for a more balanced and active life.*
Expertly formulated with adaptogenic mushrooms like reishi and organic lion’s mane to boost overall wellness and support stress responses.*
We’ve included the widely researched probiotic strain Lactobacillus acidophilus (LA-14) for maximum wellness and immune support.*
PRIMAL IMMUNE DEFENSE
HOW WILL I BENEFIT OVER TIME?
Everybody is unique and we all respond differently to changes in our wellness routines. It may take time to see results. Like with any healthy habit, commitment and consistency go a long way when it comes to realizing your wellness goals.
BENEFIT WHEN TAKEN
DAILY FOR 1 MONTH:
Many customers report feeling enhanced energy, clarity, and digestion.*
BENEFIT WHEN TAKEN
DAILY FOR 2 MONTHS:
Many customers report feeling less “run-down” and experience fewer digestive concerns.*
BENEFIT WHEN TAKEN
DAILY FOR 3+ MONTHS:
Many customers report feeling more energized and experiencing fewer symptoms of seasonal allergies and low immunity.*
Effects
PRIMAL IMMUNE DEFENSE AS A SUBSCRIPTION
EVERY 30 DAYS TO YOUR HOME
Reaping the maximum benefits from our supplements has never been so simple. With our easy and convenient subscription service you can have your Primal Immune Defense delivered right to your front door every month.
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NATURE'S BEST FOR YOU
COMPLETE INGREDIENT TRANSPARENCY
Doctor-formulated with only the highest quality ingredients, this immune support complex features a blend of pre- and probiotics, mushroom extracts, and essential vitamins & minerals with excellent bioavailability.*
HOW TO USE
HOW TO USE

Adults, as a dietary supplement, take two capsules daily, preferably with a morning or afternoon meal, or as recommended by your healthcare provider.

For best results, combine with a healthy routine that includes balanced meals, exercise, water, and plenty of rest.

SUPPLEMENT FACTS
SUPPLEMENT FACTS
Supplement facts per serving

Vitamin C (as Ascorbic Acid), Vitamin D3, Vitamin K2 (as Menaquinone MK-7), Vitamin B6 (as Pyridoxine HCL), Zinc (as Zinc AAC), Reishi (Ganderma lucidum)(Fruiting Body) 20:1 Extract 10% Polysaccharides, GOS (Galacto-oligosaccharides), Organic Lion’s Mane Mushroom (Hericium erinaceus)(Mycelium / Fruit Body), Bifidobacterium bifidum Bb-06, Lactobacillus acidophilus La-14, BioperineⓇ Black Pepper (Piper nigrum) Fruit Extract 95% Piperine. 

Other Ingredients: Vegetable Cellulose (Capsule), Microcrystalline Cellulose, Organic Rice Concentrate, Vegetable Stearate.

1. As your body adapts to your new supplement routine, it’s important to remember that every individual is different and health benefits may vary from person to person. Always consult with your physician before using this or any other product if you have a preexisting condition or take prescription medication.

2. If you are pregnant, nursing, taking medication, or have an existing condition, be sure to consult with your physician before taking this or any other dietary supplement.

CORE INGREDIENTS

Primal Immune Defense is expertly formulated with pre- and probiotics. It contains two widely studied probiotic strains, Lactobacillus acidophilus (LA-14) and Bifidobacterium bifidum (Bb-06), and premium GOS prebiotics to help maintain a healthy immune response.*

Vitamins D3, B6, C, K, and the mineral zinc are vital for immune support. This doctor-formulated blend delivers a concentrated dose of vitamins and minerals to keep you feeling your best.*

Primal Immune Defense is expertly crafted with BioPerine® black pepper extract for maximum absorption and bioavailability in doctor-approved doses.*

We’ve included reishi and organic lion’s mane for their immune-supporting and adaptogenic benefits. Used for centuries in ancient Chinese and Japanese cultures, these mushrooms may help support immune health and boost energy levels.*

CORE INGREDIENTS
Primal Harvest Primal Harvest
DON'T TAKE OUR WORD FOR IT
HEAR WHAT OUR CUSTOMERS ARE SAYING!
Customer Reviews
4.9 Based on 78 Reviews
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Filter Reviews:
KA
11/08/2022
kay a.
United States United States

stay healthy longer and be fit

it is awesome to see that I stay healthier longer. normally when someone is sick around me I am the next one. Now I am healthy even when others sick around me. Of course still get sick but not that fast and not that strong symptoms as without.

Primal Harvest Primal Immune Defense Review
A
10/24/2022
Anonymous
United States United States

Great immune support

Great product, helps me stay well and feel better than before I started taking it and gives me more energy throughout my days. Will buy again.

Primal Harvest Primal Immune Defense Review
RL
05/24/2022
Richard L.
United States United States

It works

It seems like I have more energy since I started this product, getting ready to order again

Primal Harvest Primal Immune Defense Review
A
04/29/2021
Anonymous
United States United States

Just what I needed!!!

Everything went great with the supplements! They’re easy to take in the morning and at a great price!

Primal Harvest Primal Immune Defense ReviewPrimal Harvest Primal Immune Defense Review
A Primal Harvest Customer
C
03/15/2021
CatherineG
United States United States

Has a winning formula!

Primal Harvest has a winning formula! It has vitamins C, D and Zinc for immune support. It has healthy probiotics Bfidobacterium and Lactobacillus Acidophilus and Prebiotics Galacto-oligosaccharides (GOS) for gut health. It has B6 for brain and heart health. You can't go wrong with this formula! I've felt better after taking it. I seemed to have a cold for a month and Primal Harvest helped me get over it.

Primal Harvest Primal Immune Defense Review
Primal Harvest
FREQUENTLY ASKED QUESTIONS

Primal Immune Defense is a doctor-formulated immune support blend that takes a 360° holistic approach to protecting your wellness. Primal Immune Defense contains prebiotics, probiotics, mushroom extract, vitamins, and zinc to supercharge your immune system and keep you ready to tackle whatever life throws your way.*

Probiotic strains are the different types of probiotics, also known as the beneficial bacteria found within our gut microbiota. Each strain has a different effect on the body. Some are great for digestion, while others can help to support your immune system.*

Primal Immune Defense helps you support a healthy immune system naturally. Probiotics work to optimize your microbiome and line your intestinal walls with beneficial gut bacteria. Primal Immune Defense helps deliver potent probiotic strains like Lactobacillus acidophilus (La-14) for powerful immune support. It also provides prebiotics to ensure the longevity of these immune-boosting probiotic strains.*

Primal Immune Defense is loaded with vitamins C, D3, B6, K, zinc, and mushroom extracts to help strengthen your natural defenses.*

We recommend that you take your 2 capsules daily with your morning breakfast, brunch, or afternoon lunch. Since consistency is key to getting the most out of your Immune Defense, we recommend picking a time and sticking to it each day.

Each bottle contains 30 servings (or a one-month supply).

This product is manufactured in a facility that also processes tree nuts, peanuts, wheat, and soy. Always review the label closely for the most accurate information, and check with your doctor if you have any concerns.

Primal Immune Defense is intended for use by healthy adults over 18 years old. We recommend that you consult with your physician before use if you are taking any prescription or over-the-counter medications or are being treated for any existing medical conditions.

We have formulated this product to be shelf-stable with a significant overage on total cell enumeration. Probiotic bacteria can be sensitive to certain environments, that’s why we keep them temperature controlled throughout the entire production process, including storage in our warehouse.

Although Primal Immune Defense is shelf-stable and specially formulated to maintain maximum efficiency and shelf life, we recommend storing it in a cool, dry place away from moisture, and outside of direct sunlight. Although it’s not required, you can refrigerate your product after opening.

Stability studies show that full potency and cell count will be maintained for 18+ months if stored properly and unopened. After 18 months, the probiotic is at risk of a decrease in potency and cell count. Once opened, we recommend finishing an opened bottle within 90 days and storing the opened bottle either in low-moisture conditions.

To take full advantage of our discounts and to help you remain consistent with your routine, we recommend buying multiple bottles of Primal Immune Defense. You are always protected by our 90-day money-back guarantee so you have plenty of time to enjoy the long term benefits of Primal Immune Defense and make sure it’s the right fit for you. Please have a look at “What is the shelf life of my Primal Immune Defense?” to learn more.

If you are using a discount code, please note that your discount code cannot be combined with any other offer or discount code and excludes all sale items and subscription purchases.

Primal Immune Defense is formulated and manufactured in the USA in a GMP-certified facility (Good Manufacturing Practices) according to the highest safety and quality regulations. It is independently third party lab-tested in the USA and is formulated with premium globally sourced ingredients (both domestic and imported) to ensure we use only the best ingredients available worldwide.†

*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information provided by this website or this company is not a substitute for a face-to-face consultation with your physician and should not be construed as individual medical advice. The testimonials on this website are individual cases and do not guarantee that you will get the same results. All content, including text, graphics, images and information, contained on or available through this web site is for general information purposes only.

EVALUATION OF SELECTED CULINARY-MEDICIAN MUSHROOMS FOR ANTIOXIDANT AND ACE INHIBITORY ACTIVITIES

Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities. Evid Based Complement Alternat Med. 2012;2012:464238. doi:10.1155/2012/464238.

VITAMIN D AND THE IMMUNE SYSTEM

Aranow C. Vitamin D and the Immune System. J Investig Med. 2011 Aug;59(6):881-6. doi: 10.2310/JIM.0b013e31821b8755. PMID: 21527855; PMCID: PMC3166406. 

VITAMIN C AND IMMUNE FUNCTION

Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017 Nov 3;9(11):1211. doi: 10.3390/nu9111211. PMID: 29099763; PMCID: PMC5707683. 

INFLAMMATORY RESPONSES AND INFLAMMATION-ASSOCIATED DISEASES IN ORGANS

Chen L, Deng H, Cui H, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017;9(6):7204-7218. Published 2017 Dec 14. doi:10.18632/oncotarget.23208. 

VITAMIN D3: A HELPFUL IMMUNO-MODULATOR

Di Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L. Vitamin D3: a helpful immuno-modulator. Immunology. 2011;134(2):123-139. doi:10.1111/j.1365-2567.2011.03482.x. 

EFFECT OF VITAMIN C ON INFLAMMATION AND METABOLIC MARKERS IN HYPERTENSIVE AND/OR DIABETIC OBESE ADULTS: A RANDOMIZED CONTROLLED TRIAL

Ellulu MS, Rahmat A, Patimah I, Khaza'ai H, Abed Y. Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial. Drug Des Devel Ther. 2015;9:3405-3412. Published 2015 Jul 1. doi:10.2147/DDDT.S83144. 

CHEMISTRY, NUTRITION, AND HEALTH-PROMOTING PROPERTIES OF HERICIUM ERINACEUS (LION’S MANE) MUSHROOM FRUITING BODIES AND MYCELIA AND THEIR BIOACTIVE COMPOUNDS

Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. J Agric Food Chem. 2015;63(32):7108-7123. doi:10.1021/acs.jafc.5b02914.

THE IMPORTANCE OF VITAMINS D AND K FOR THE BONE HEALTH AND IMMUNE FUNCTION IN INFLAMMATORY BOWEL DISEASE

Iijima H, Shinzaki S, Takehara T. The importance of vitamins D and K for the bone health and immune function in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care. 2012;15(6):635-640. doi:10.1097/MCO.0b013e328357f623.

ANTIINFLAMMATORY AND IMMUNOMODULATING PROPERTIES OF FUNGAL METABOLITES

Lull C, Wichers HJ, Savelkoul HF. Antiinflammatory and immunomodulating properties of fungal metabolites. Mediators Inflamm. 2005;2005(2):63-80. doi:10.1155/MI.2005.63.

OFFICE OF DIETARY SUPPLEMENTS - VITAMIN C

Office of Dietary Supplements - Vitamin C. https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/. Accessed March 4, 2021. 

ZINC IN HUMAN HEALTH: EFFECT OF ZINC ON IMMUNE CELLS

Prasad, A.S.. Zinc in Human Health: Effect Of Zinc on Immune Cells. Mol Med. 2008; 14(5-6): 353-357. 

BIFIDOBACTERIA AND THEIR MOLECULAR COMMUNICATION WITH THE IMMUNE SYSTEM

Ruiz L, Delgado S, Ruas-Madiedo P, Sánchez B, Margolles A. Bifidobacteria and Their Molecular Communication with the Immune System. Front Microbiol. 2017;8:2345. Published 2017 Dec 4. doi:10.3389/fmicb.2017.02345.  

ZINC AND IMMUNE FUNCTION: THE BIOLOGICAL BASIS OF ALTERED RESISTANCE TO INFECTION

Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr. 1998;68(2 Suppl):447S-463S. doi:10.1093/ajcn/68.2.447S. 

TECHNICAL MEMORANDUM: LACTOBACILLUS ACIDOPHILUS LA-14  

Technical Memorandum: Lactobacillus Acidophilus La-14. Danisco. (6AD, January). Accessed March 4, 2021, http://ss1.spletnik.si/4_4/000/000/19f/152/La-14 TM.pdf. 

EDIBLE MUSHROOMS: IMPROVING HUMAN HEALTH AND PROMOTING QUALITY LIFE

Valverde ME, Hernández-Pérez T, Paredes-López O. Edible mushrooms: improving human health and promoting quality life. Int J Microbiol. 2015;2015:376387. doi:10.1155/2015/376387. 

IMMUNE-ENHANCING ROLE OF VITAMIN C AND ZINC AND EFFECT ON CLINICAL CONDITIONS

Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85-94. doi: 10.1159/000090495. Epub 2005 Dec 21. PMID: 16373990. 

PREBIOTICS IN THE GASTROINTESTINAL TRACT

Macfarlane S. Prebiotics in the gastrointestinal tract. Bioactive Foods in Promoting Health. 2010:145-156. doi:10.1016/b978-0-12-374938-3.00010-4