THE ULTIMATE GUT RESTORE FORMULA
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Adults, as a dietary supplement, take two capsules daily, preferably with a morning or afternoon meal and water, or as recommended by your healthcare provider.
For best results, combine with a healthy routine that includes balanced meals, exercise, water, and plenty of rest.
CoreBiome® Tributyrin, Xylooligosacchardies, B. longum BB536®.
Other Ingredients: Pullan (Vegetable Capsule), Magnesium Stearate, Activated Charcoal (from Coconut Shells), Silicon Dioxide, Microcrystalline Cellulose.
1. As your body adapts to your new supplement routine, it’s important to remember that every individual is different and health benefits may vary from person to person. Always consult with your physician before using this or any other product if you have a preexisting condition or take prescription medication.
2. If you are pregnant, nursing, taking medication, or have an existing condition, be sure to consult with your physician before taking this or any other dietary supplement.
Prebiotics promote the growth of healthy bacteria in your gut (probiotics) and through fermentation, may help produce important short-chain fatty acids (SCFAs).*
Our xylooligosaccharide prebiotics powerfully target and promote the benefits of the specific gut-boosting probiotics we’ve included in our Primal Gut Restore formula. Prebiotics may even help ward off cravings and help keep you feeling full for longer.*
This groundbreaking postbiotic is the unique derivative of a short-chain fatty-acid known as butyrate, which is naturally produced by healthy bacteria in your gut. Butyrate is the primary fuel source for the cells of your gut lining, and is especially important for digestive health, gut barrier function, and immune support.*
As the only tributyrin the world with clinical data showing it reaches the colon, CoreBiome® is considered the #1 postbiotic in the world for promoting overall wellness and gut health.*
This multifunctional, wellness-boosting probiotic strain has been shown to be highly effective for supporting various digestive concerns. It helps support healthy digestion and immune function, as well as improved regularity and energy levels.*
B. longum BB536® may also be more stable and possess a longer shelf life when compared to other probiotic strains.*
Primal Gut Restore is the ultimate formula for complete gut support. It is formulated with a powerful combination of prebiotics, probiotics, and CoreBiome® postbiotics. Primal Gut Restore supplies your body with important elements needed to support a healthy gut lining, gut flora, and support digestion, regularity, natural defenses, and overall wellness.*
Did you know that approximately 70% of the body's immune cells are located within your gut? Primal Gut Restore is the ultimate gut support supplement that takes everything into consideration, with premium prebiotics, probiotics, and postbiotics. You wouldn’t build a house on sand, so why would you invest in probiotics without creating the perfect environment for them to survive and thrive? Primal Gut Restore gives you a complete approach to naturally supporting your gut from every angle.*
Your gut flora, also known as the gut microbiome or microbiota, refers to the microorganisms that live in our gut. It’s made up of bacteria, archaea, and fungi and plays a huge role in our gut, immune, and overall wellness. The key to maintaining a healthy gut and trying to restore gut health is to keep the microbiota balanced between the “good” and “bad” bacteria.*
Probiotic strains, sometimes also thought of as healthy gut bacteria, are the different types of probiotics that have been isolated and defined by scientists for their potential to support human health. Various strains have different effects on the body: some are great for digestion, while others are beneficial for immune support, for example. You already have well over 500 different probiotic strains in your body at any given moment.*
Prebiotics are the non-digestible fiber found in many foods. These prebiotics pass through your small intestine and then become fermented before they reach the large intestine. It’s here that prebiotics serve as a food source for probiotics, allowing them to grow and thrive within your gut microbiome.*
Postbiotics are what is created when prebiotics are used by probiotics. They are the beneficial “waste” of probiotics, in a sense, and they are actually where many of the benefits of probiotics may be produced. Primal Gut Restore includes a total blend of prebiotics, probiotics, and CoreBiome® postbiotics to deliver a complete three-step approach to supporting a healthy gut.*
Short-chain fatty acids are essential to a healthy mind, body, and gut. CoreBiome® is a unique derivative of a short-chain fatty-acid known as butyrate, which is naturally produced by healthy bacteria in our gut when we eat certain foods. Butyrate is the primary fuel source for the cells of our gut lining, and thus supports digestive health and immune function. While “regular” butyrate is primarily used in the stomach and small intestine, groundbreaking CoreBiome® gets to the colon where it is most needed to support immune health and overall well-being. This is fundamentally important and explains why CoreBiome® is the single most important postbiotic on the market today when it comes to supporting a healthy gut.*
Primal Gut Restore comes in easy-to-swallow capsules that are taken once daily. Simply take two capsules daily, preferably with or with a morning or afternoon meal. For best results, use consistently each day.
Primal Gut Restore is perfectly formulated for vegetarians, as well as various other types of dietary restrictions. It contains no dairy, eggs, gluten, or soy. We recommend reading the label closely before deciding if Primal Gut Restore is the right choice for you.
Each bottle of Primal Gut Restore contains 30 servings (60 capsules), or a one-month supply, if taken daily.
This product contains activated charcoal from coconut shells. It is manufactured in a facility that also processes tree nuts, peanuts, wheat, and soy. Always review the details on the product label for the most accurate information and when in doubt, we always recommend consulting with a personal physician regarding existing allergies or health concerns.
Primal Gut Restore is intended for use by healthy adults over the age of 18. If you have a pre-existing condition, take prescription medications, or have any medical concerns, we always recommend consulting with your personal physician before starting a new supplement routine.
We have formulated this product to be shelf-stable with a significant overage on total cell enumeration. Probiotic bacteria can be sensitive to certain environments, that’s why we keep them temperature controlled throughout the entire production process, including storage in our warehouse. Although Primal Gut Restore is shelf-stable and specially formulated to maintain maximum efficiency and shelf life, we recommend storing it in a cool, dry place away from moisture, and outside of direct sunlight. Although it’s not required, you can refrigerate your product after opening.
If stored properly and unopened, Primal Gut Restore should generally retain its shelf life for about two years. Once opened, we recommend using the product within 90 days for maximum effectiveness. Each bottle contains a 30-day supply if taken daily.
This is totally up to you! Since consistency is the key to maximum benefits, we recommend taking advantage of our discounts when you purchase six or more bottles of Primal Gut Restore. You are always protected by our 90-day money-back guarantee, which allows for plenty of time to try Primal Gut Restore and decide if it is the right product for you. If you are using a discount code, please note that your discount code cannot be combined with any other offer or discount code and excludes all sale items and subscription purchases.
Primal Gut Restore is formulated and manufactured in the USA in a GMP-certified facility (Good Manufacturing Practices) according to the highest safety and quality regulations. It is independently third-party lab-tested in the USA and is formulated with premium globally sourced ingredients (both domestic and imported) to ensure we use only the best ingredients available worldwide.†
*These statements have not been evaluated by the FDA Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information provided by this website or this company is not a substitute for a face-to-face consultation with your physician and should not be construed as individual medical advice. The testimonials on this website are individual cases and do not guarantee that you will get the same results. All content, including text, graphics, images and information, contained on or available through this web site is for general information purposes only.
Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol. 2011;17(12):1519-1528. doi:10.3748/wjg.v17.i12.1519.COREBIOME TRIBUTYRIN: THE SOURCE OF WELLNESS
CoreBiome Tirutryin: The Source of Wellness. Compound Solutions. https://compoundsolutions.com/corebiome-tributyrin-the-source-of-wellness/. Published January 13 2021. Accessed June 7 2021.XYLOOLIGOSACCHARIDE MODULATES GUT MICROBIOTA AND ALLEVIATES COLONIC INFLAMMATION CAUSED BY HIGH FAT DIET INDUCED OBESITY
Fei, Yanquan et al. Frontiers in physiology vol. 10 1601. 22 Jan. 2020, doi:10.3389/fphys.2019.01601.TRIBUTYRIN SUPPLEMENTATION PROTECTS IMMUNE RESPONSES AND VASCULATURE AND REDUCES OXIDATIVE STRESS IN THE PROXIMAL COLON OF MICE EXPOSED TO CHRONIC-BINGE ETHANOL FEEDING
Glueck B, Han Y, Cresci GAM. Tributyrin Supplementation Protects Immune Responses and Vasculature and Reduces Oxidative Stress in the Proximal Colon of Mice Exposed to Chronic-Binge Ethanol Feeding. J Immunol Res. 2018;2018:9671919. Published 2018 Aug 19. doi:10.1155/2018/9671919.IMPROVEMENT OF LACTOSE DIGESTION IN HUMANS BY INGESTION OF UNFERMENTED MILK CONTAINING
Jiang T, Mustapha A, Savaiano DA. Improvement of lactose digestion in humans by ingestion of unfermented milk containing Bifidobacterium longum. J Dairy Sci. 1996;79(5):750-757. doi:10.3168/jds.S0022-0302(96)76422-6.EFFECTS OF MONOBUTYRIN AND TRIBUTYRIN ON LIVER LIPID PROFILE, CAECAL MICROBIOTA COMPOSITION AND SCFA IN HIGH-FAT DIET-FED RATS
Nguyen TD, Prykhodko O, Fåk Hållenius F, Nyman M. Effects of monobutyrin and tributyrin on liver lipid profile, caecal microbiota composition and SCFA in high-fat diet-fed rats. J Nutr Sci. 2017;6:e51. Published 2017 Oct 11. doi:10.1017/jns.2017.54.BIFIDOBACTERIA AND THEIR ROLE AS MEMBERS OF THE HUMAN GUT MICROBIOTA
O'Callaghan A, van Sinderen D. Bifidobacteria and Their Role as Members of the Human Gut Microbiota. Front Microbiol. 2016;7:925. Published 2016 Jun 15. doi:10.3389/fmicb.2016.00925.BUTYRATE ENHANCES THE INTESTINAL BARRIER BY FACILITATING TIGHT JUNCTION ASSEMBLY VIA ACTIVATION OF AMP-ACTIVATED PROTEIN KINASE IN CACO-2 CELL MONOLAYERS
Peng L, Li ZR, Green RS, Holzman IR, Lin J. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. J Nutr. 2009;139(9):1619-1625. doi:10.3945/jn.109.104638.CARBOHYDRATE METABOLISM IN BIFIDOBACTERIA
Pokusaeva K, Fitzgerald GF, van Sinderen D. Carbohydrate metabolism in Bifidobacteria. Genes Nutr. 2011;6(3):285-306. doi:10.1007/s12263-010-0206-6.EFFECTS OF XYLOOLIGOSACCHARIDES IN TYPE 2 DIABETES MELLITUS
Sheu WH, Lee IT, Chen W, Chan YC. Effects of xylooligosaccharides in type 2 diabetes mellitus. J Nutr Sci Vitaminol (Tokyo). 2008;54(5):396-401. doi:10.3177/jnsv.54.396.INFLUENCE OF DIET ON THE GUT MICROBIOME AND IMPLICATIONS FOR HUMAN HEALTH
Singh RK, Chang HW, Yan D, et al. Influence of diet on the gut microbiome and implications for human health. J Transl Med. 2017;15(1):73. Published 2017 Apr 8. doi:10.1186/s12967-017-1175-y.EFFECTS OF TRIBUTYRIN SUPPLEMENTATION ON GROWTH PERFORMANCE... IN WEANED PIGLETS
Sotira S, Dell'Anno M, Caprarulo V, et al. Effects of Tributyrin Supplementation on Growth Performance, Insulin, Blood Metabolites and Gut Microbiota in Weaned Piglets. Animals (Basel). 2020;10(4):726. Published 2020 Apr 22. doi:10.3390/ani10040726.EFFECT OF PROBIOTIC BIFIDOBACTERIUM LONGUM BB536 [CORRECTED] IN RELIEVING CLINICAL SYMPTOMS AND MODULATING PLASMA CYTOKINE LEVELS OF JAPANESE CEDAR POLLINOSIS DURING THE POLLEN SEASON. A RANDOMIZED DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
Xiao JZ, Kondo S, Yanagisawa N, et al. Effect of probiotic Bifidobacterium longum BB536 [corrected] in relieving clinical symptoms and modulating plasma cytokine levels of Japanese cedar pollinosis during the pollen season. A randomized double-blind, placebo-controlled trial [published correction appears in J Investig Allergol Clin Immunol. 2006;16(4):273]. J Investig Allergol Clin Immunol. 2006;16(2):86-93.BUTYRATE SHAPES IMMUNE CELL FATE AND FUNCTION IN ALLERGIC ASTHMA
Yip W, Hughes MR, Li Y, Cait A, Hirst M, Mohn WW, McNaghny KM. Butyrate shames immune cell fate and function in allergic asthma. Front Immunol. 2021 (12):628453. doi: 10.3389/fimmu.2021.628453.CLINICAL EFFECTS OF PROBTIOCS BIFIDOBACTERIUM LONGUM BB536 ON IMMUNE FUNCTION AND INTESTINAL MICROBIOTA IN ELDERLY PATIENTS RECEVING ENTERAL TUBE FEEDING
Akatsu H, Iwabuchi N, Xiao JZ, et al. Clinical effects of probiotic Bifidobacterium longum BB536 on immune function and intestinal microbiota in elderly patients receiving enteral tube feeding. JPEN J Parenter Enteral Nutr. 2013;37(5):631-640. doi:10.1177/0148607112467819.GUT MICROBIOTA FERMENTATION OF PREBIOTICS INCREASES SATIETOGENIC AND ICNRETIN GUT PEPTIDE PRODUCTION WITH CONSEQUENCES FOR APPETITE SENSATION AND GLUCOSE RESPONSE AFTER A MEAL
Cani PD, Lecourt E, Dewulf EM, et al. Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am J Clin Nutr. 2009;90(5):1236-1243. doi:10.3945/ajcn.2009.28095.GUT MICROFLORA AS A TARGET FOR ENERGY AND METABOLIC HOMEOSTASIS
Cani PD, Delzenne NM. Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care. 2007;10(6):729-734. doi:10.1097/MCO.0b013e3282efdebbTHE ROLE OF PROBIOTICS AND PREBIOTICS IN THE PREVENTION AND TREATMENT OF OBESITY
Cerdó T, García-Santos JA, G Bermúdez M, Campoy C. The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity. Nutrients. 2019;11(3):635. Published 2019 Mar 15. doi:10.3390/nu11030635LACTOBACILLUS GG AND TRIBUTYRIN SUPPLEMENTATION REDUCE ANTIBIOTIC-INDUCED INTESTINAL INJURY
Cresci, G. Lactobacillus GG and tributyrin supplementation reduce antibiotic-induced intestinal injury. Journal of Parenteral and Enteral Nutrition. 2013.SODIUM BUTYRATE EPIGENETICALLY MODULATES HIGH-FAT DIET-INDUCED SKELETAL MUSCLE MITOCHONDRIAL ADAPTATION
Henegan, T. Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning. British Journal of Pharmacology. 2015.BUTYRATE ALLEVIATES HIGH FAT DIET-INDUCED OBESITY THROUGH ADIPONECTIN-MEDIATED PATHWAY AND STIMULATION OF MITOCHONDIRAL FUNCTION IN SKELETAL MUSCLE OF MICE
Hong, J. Butyrate alleviates high fat diet-induced obesity through adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice. Oncotarget. 2016.BIFIDOBACTERIUM LONGUM BB536 ALLEVIATED UPPER RESPIRATORY ILLNESSES AND MODULATED GUT MICROBIOTA PROFILES IN MALAYSIAN PRE-SCHOOL CHILDREN
Lau AS, Yanagisawa N, Hor YY, et al. Bifidobacterium longum BB536 alleviated upper respiratory illnesses and modulated gut microbiota profiles in Malaysian pre-school children. Benef Microbes. 2018;9(1):61-70. doi:10.3920/BM2017.0063.BUTYRATE REDUCES APPETITE AND ACTIVATES BROWN ADIPOSE TISSUE WITH THE GUT-BRAIN NEURAL CIRCUIT
Li, Z. Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit. Gut Microbiota. 2018.PROBIOTICS AND ATHLETIC PERFORMANCE: A SYSTEMATIC REVIEW
Nichols AW. Probiotics and athletic performance: a systematic review. Curr Sports Med Rep. 2007;6(4):269-273.