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Folate vs. Folic Acid: What's The Difference?

Folate vs. Folic Acid: What's The Difference?

Folate and folic acid are terms often used interchangeably, but they are not the same thing. Both are forms of vitamin B9, a crucial nutrient for various bodily functions, especially when it comes to women's wellness – which is why you’ll often hear about them when it comes to prenatal or women’s support vitamins.

However, there are key differences between the two that you may want to consider. Let’s break down these differences and talk a little bit about other key nutrients for women’s health and pregnancy. 

What Is Folate?

Folate is the naturally occurring form of vitamin B9 found in various foods. It's a water-soluble B vitamin essential for DNA synthesis, cell growth, and overall health. Folate is abundant in many foods, including: 

  • Leafy greens (like spinach and kale)
  • Legumes
  • Asparagus
  • Citrus fruits

What Is Folic Acid?

Folic acid, on the other hand, is the synthetic form of vitamin B9. It's created by converting naturally occurring folate into a more stable and bioavailable form, primarily for use in supplements and fortified foods. Folic acid is crucial for preventing neural tube defects during pregnancy and is widely used in prenatal vitamins.

Key Differences: Folate vs. Folic Acid


Folate: Found naturally in foods.

Folic Acid: Synthetic and used in supplements and fortified foods.



Folate: Easily absorbed in the small intestine.

Folic Acid: Needs to be converted into the active form of folate (5-MTHF) by the body before it can be used.



Folate: The naturally occurring form, so it's readily available for use by the body.

Folic Acid: Requires conversion to the active form, which can be less efficient in some individuals.


Folate: Adequate folate intake during pregnancy is vital for preventing neural tube defects and supporting fetal development.

Folic Acid: Folic acid supplementation is commonly recommended to pregnant women to ensure they meet their folate needs.


Methylation Process:

Folate: Plays a crucial role in the methylation process, which is essential for DNA repair and regulation of gene expression.

Folic Acid: The conversion of folic acid into the active form (5-MTHF) is necessary for these methylation processes.


Health Conditions:

Folate: Some individuals may have difficulty converting folate to its active form due to genetic variations, potentially leading to health issues.

Folic Acid: Can be an effective alternative for those who have trouble converting folate.


More key nutrients for women’s health and pregnancy... 

Women's health, especially during pregnancy, requires a range of essential nutrients to support both the mother's well-being and fetal development. Here are some key nutrients crucial for women's health and pregnancy:

Iron: Iron is essential for preventing anemia, which is common during pregnancy due to increased blood volume. Adequate iron intake supports oxygen transport to both the mother and the growing fetus.

Calcium: Calcium is vital for the development of the baby's bones and teeth. It also helps maintain the mother's bone health, as the growing fetus can draw calcium from the mother's bones.

Vitamin D: Vitamin D is necessary for calcium absorption and bone health. It also plays a role in the immune system and overall well-being.

Omega-3 Fatty Acids: Omega-3s, particularly DHA (docosahexaenoic acid), are essential for the development of the baby's brain and eyes. They also support the mother's cardiovascular health.

Fiber: Adequate fiber intake helps prevent constipation, a common issue during pregnancy, by promoting regular bowel movements.

Protein: Protein is crucial for the development of the baby's organs, muscles, and tissues. It also supports the mother's increased blood volume and helps repair and build tissues.

Vitamin C: Vitamin C aids in the absorption of iron and supports the immune system. It also plays a role in collagen production, which is essential for skin, ligaments, and blood vessels.

Folate (as mentioned): Folate is essential for preventing neural tube defects and supporting cell growth and development.

Vitamin B6: This vitamin is involved in the development of the baby's brain and nervous system. It can also help alleviate symptoms of morning sickness.

Vitamin B12: Vitamin B12 is necessary for nerve function and the formation of red blood cells. A deficiency can lead to anemia and neurological issues.

Choline: Choline supports brain development and overall cognitive function in both the mother and baby. It's especially important during pregnancy when the demand for choline increases.

Zinc: Zinc is essential for cell division, which is critical during fetal development. It also supports the immune system and wound healing.

Iodine: Iodine is necessary for thyroid function and the production of thyroid hormones. Adequate iodine intake is crucial for the baby's brain development and the mother's overall health.

Magnesium: Magnesium supports muscle function, bone health, and the mother's energy production. It can also help alleviate pregnancy-related muscle cramps and contractions.

Vitamin A: Vitamin A is essential for vision, immune function, and skin health. However, excessive vitamin A intake during pregnancy can be harmful, so it's essential to get it from food sources rather than supplements.


Remember that a balanced diet rich in whole foods, including fruits, vegetables, lean proteins, whole grains, and dairy products (or suitable alternatives), is the best way to obtain these essential nutrients. However, prenatal supplements may be recommended to fill in potential gaps in the diet, but it's essential to consult with a healthcare provider before taking any supplements during pregnancy.


While both folate and folic acid are essential forms of vitamin B9, the source and form of these nutrients differ significantly. Folate is found naturally in foods and is readily available for use by the body, making it an excellent choice for most people. Folic acid, in contrast, is synthetic and requires conversion before the body can utilize it effectively.

Understanding the distinctions between folate and folic acid is crucial, particularly during pregnancy and for individuals with specific genetic variations affecting folate metabolism. Consult with a healthcare professional to determine the best approach for meeting your vitamin B9 needs, whether through dietary sources or supplementation, to support your overall health and well-being.

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